Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia.
Identifieur interne : 000360 ( Main/Exploration ); précédent : 000359; suivant : 000361Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia.
Auteurs : Carla Abdelnour [Espagne] ; Inger Van Steenoven [Pays-Bas] ; Elisabet Londos [Suède] ; Frédéric Blanc [France] ; Bj Rn Auestad [Norvège] ; Milica G. Kramberger [Slovénie] ; Henrik Zetterberg [Suède] ; Brit Mollenhauer [Allemagne] ; Mercè Boada [Espagne] ; Dag Aarsland [Norvège]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
Alzheimer's disease pathologies are common in dementia with Lewy bodies, but their clinical relevance is not clear. CSF biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect Alzheimer's disease neuropathology antemortem. In PD, low CSF amyloid beta 1-42 predict long-term cognitive decline, but little is known about these biomarkers as predictors for cognitive decline in Lewy body dementia. The aim of this study was to assess whether Alzheimer's disease CSF biomarkers predict cognitive decline in Lewy body dementia.
DOI: 10.1002/mds.26668
PubMed: 27296778
Affiliations:
- Allemagne, Espagne, France, Norvège, Pays-Bas, Slovénie, Suède
- Alsace (région administrative), Basse-Saxe, Catalogne, Grand Est, Hollande-Septentrionale
- Amsterdam, Barcelone, Göttingen, Strasbourg
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decline in lewy body dementia.</title><author><name sortKey="Abdelnour, Carla" sort="Abdelnour, Carla" uniqKey="Abdelnour C" first="Carla" last="Abdelnour">Carla Abdelnour</name><affiliation wicri:level="3"><nlm:affiliation>Fundació ACE, Alzheimer Research Center and Memory Clinic, Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundació ACE, Alzheimer Research Center and Memory Clinic, Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Van Steenoven, Inger" sort="Van Steenoven, Inger" uniqKey="Van Steenoven I" first="Inger" last="Van Steenoven">Inger Van Steenoven</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Londos, Elisabet" sort="Londos, Elisabet" uniqKey="Londos E" first="Elisabet" last="Londos">Elisabet Londos</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name><affiliation wicri:level="3"><nlm:affiliation>Neuropsychology Unit and Geriatric Day Hospital (Strasbourg Resource and Research Memory Center, CMRR), University Hospital of Strasbourg and ICube laboratory, FMTS, University of Strasbourg and CNRS, Strasbourg, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuropsychology Unit and Geriatric Day Hospital (Strasbourg Resource and Research Memory Center, CMRR), University Hospital of Strasbourg and ICube laboratory, FMTS, University of Strasbourg and CNRS, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Auestad, Bj Rn" sort="Auestad, Bj Rn" uniqKey="Auestad B" first="Bj Rn" last="Auestad">Bj Rn Auestad</name><affiliation wicri:level="1"><nlm:affiliation>Research Department, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Research Department, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Kramberger, Milica G" sort="Kramberger, Milica G" uniqKey="Kramberger M" first="Milica G" last="Kramberger">Milica G. Kramberger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Medical Center, Ljubljana, Slovenia.</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department of Neurology, University Medical Center, Ljubljana</wicri:regionArea><wicri:noRegion>Ljubljana</wicri:noRegion></affiliation></author><author><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal</wicri:regionArea><wicri:noRegion>Mölndal</wicri:noRegion></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="3"><nlm:affiliation>Paracelsus-Elena-Klinik, Kassel and University Medical Center, Department of Neurosurgery and Institute of Neuropathology, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel and University Medical Center, Department of Neurosurgery and Institute of Neuropathology, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name><affiliation wicri:level="3"><nlm:affiliation>Fundació ACE, Alzheimer Research Center and Memory Clinic, Institut Català de Neurociències Aplicades, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundació ACE, Alzheimer Research Center and Memory Clinic, Institut Català de Neurociències Aplicades, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation wicri:level="1"><nlm:affiliation>Research Department, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Research Department, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alzheimer's disease pathologies are common in dementia with Lewy bodies, but their clinical relevance is not clear. CSF biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect Alzheimer's disease neuropathology antemortem. In PD, low CSF amyloid beta 1-42 predict long-term cognitive decline, but little is known about these biomarkers as predictors for cognitive decline in Lewy body dementia. The aim of this study was to assess whether Alzheimer's disease CSF biomarkers predict cognitive decline in Lewy body dementia.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>France</li><li>Norvège</li><li>Pays-Bas</li><li>Slovénie</li><li>Suède</li></country><region><li>Alsace (région administrative)</li><li>Basse-Saxe</li><li>Catalogne</li><li>Grand Est</li><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Göttingen</li><li>Strasbourg</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Abdelnour, Carla" sort="Abdelnour, Carla" uniqKey="Abdelnour C" first="Carla" last="Abdelnour">Carla Abdelnour</name></region><name sortKey="Boada, Merce" sort="Boada, Merce" uniqKey="Boada M" first="Mercè" last="Boada">Mercè Boada</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van Steenoven, Inger" sort="Van Steenoven, Inger" uniqKey="Van Steenoven I" first="Inger" last="Van Steenoven">Inger Van Steenoven</name></region></country><country name="Suède"><noRegion><name sortKey="Londos, Elisabet" sort="Londos, Elisabet" uniqKey="Londos E" first="Elisabet" last="Londos">Elisabet Londos</name></noRegion><name sortKey="Zetterberg, Henrik" sort="Zetterberg, Henrik" uniqKey="Zetterberg H" first="Henrik" last="Zetterberg">Henrik Zetterberg</name></country><country name="France"><region name="Grand Est"><name sortKey="Blanc, Frederic" sort="Blanc, Frederic" uniqKey="Blanc F" first="Frédéric" last="Blanc">Frédéric Blanc</name></region></country><country name="Norvège"><noRegion><name sortKey="Auestad, Bj Rn" sort="Auestad, Bj Rn" uniqKey="Auestad B" first="Bj Rn" last="Auestad">Bj Rn Auestad</name></noRegion><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name></country><country name="Slovénie"><noRegion><name sortKey="Kramberger, Milica G" sort="Kramberger, Milica G" uniqKey="Kramberger M" first="Milica G" last="Kramberger">Milica G. Kramberger</name></noRegion></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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